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These uncertainties arise because of ourinability to directly measure the actual human threshold dose.The weaker the data set available for evaluation (few studies,limited doses tested, etc.) and the more assumptions required,the greater the uncertainty that the nOAeL or LOAeL fromthe literature actually represents the threshold dose in humans.The purpose of dividing the nOAeL, LOAeL, or BMD byuncertainty factors is to ensure that the SHD used in the riskassessment is below the actual human threshold dose fortoxicity for all individuals in the exposedpopulation,therebyavoiding any underestimation of risk. Several trials have shown excellent results with early switch to oralmedication.

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Les grew up near Liverpool in the UK. He was a police officer for 22 years and a missionary in Romania. He’s discovered that God uses even the most difficult times of our lives. In our previous podcast, you heard part one of Les’ story. We were sitting around the dinner table with him and […]

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